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A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor

Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein called neurofibromin and is one of several genes that (when mutant) affect RAS–MAPK signalling, causing related diseases collectively kno...

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Publicado en:Nat Rev Cancer
Autores principales: Ratner, Nancy, Miller, Shyra J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822336/
https://ncbi.nlm.nih.gov/pubmed/25877329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3911
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