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Drugging the undruggables: exploring the ubiquitin system for drug development
Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried out by the ubiquitin-proteasome system (UPS). Similar to kinases, components of the ubiquitin system are often dysregulated, leading to a varie...
Gespeichert in:
| Veröffentlicht in: | Cell Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822129/ https://ncbi.nlm.nih.gov/pubmed/27002218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.31 |
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