Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) deficiency in small airways has been reported in COPD patients, we hypothesized that immunobarrier dysfunction resulting from reduced SI...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Richmond, Bradley W., Brucker, Robert M., Han, Wei, Du, Rui-Hong, Zhang, Yongqin, Cheng, Dong-Sheng, Gleaves, Linda, Abdolrasulnia, Rasul, Polosukhina, Dina, Clark, Peter E., Bordenstein, Seth R., Blackwell, Timothy S., Polosukhin, Vasiliy V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822073/
https://ncbi.nlm.nih.gov/pubmed/27046438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11240
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