Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium

BACKGROUND: Glutathione S-transferase M1 (GSTM1) is a Phase II enzyme and regulator of inflammatory signaling in airway epithelial cells. We have found upregulation of neutrophilic airway inflammation in atopic asthmatics expressing GSTM1 gene (GSTM1+) compared to GSTM1null asthmatics. We hypothesiz...

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Publicado en:Allergy
Autores principales: Polosukhin, Vasiliy V., Polosukhin, Igor V., Hoskins, Aimee, Han, Wei, Abdolrasulnia, Rasul, Blackwell, Timothy S., Dworski, Ryszard
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317365/
https://ncbi.nlm.nih.gov/pubmed/25118837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.12506
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