Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

Previously, we reported that ATXN1 oligomers are the primary drivers of toxicity in Spinocerebellar ataxia type 1 (SCA1; Lasagna-Reeves et al., 2015). Here we report that polyQ ATXN1 oligomers can propagate locally in vivo in mice predisposed to SCA1 following intracerebral oligomeric tissue inocula...

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Bibliographic Details
Published in:eLife
Main Authors: Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Munoz, Marcos J, Vilanova-Velez, Luis, Park, Jeehye, See, Lauren, Jafar-Nejad, Paymaan, Richman, Ronald, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821792/
https://ncbi.nlm.nih.gov/pubmed/26673892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10891
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