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The Interactions of P-Glycoprotein with Antimalarial Drugs, Including Substrate Affinity, Inhibition and Regulation

The combination of passive drug permeability, affinity for uptake and efflux transporters as well as gastrointestinal metabolism defines net drug absorption. Efflux mechanisms are often overlooked when examining the absorption phase of drug bioavailability. Knowing the affinity of antimalarials for...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Senarathna, S M D K Ganga, Page-Sharp, Madhu, Crowe, Andrew
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821601/
https://ncbi.nlm.nih.gov/pubmed/27045516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152677
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