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Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs

Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 μM) and low for naphthoquine (5 μM). With 20 μM naphthoquine, net efflux was blocked, suggesting saturation of the transport...

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Detalhes bibliográficos
Main Authors: Crowe, Andrew, Ilett, Kenneth F., Karunajeewa, Harin A., Batty, Kevin T., Davis, Timothy M. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1610088/
https://ncbi.nlm.nih.gov/pubmed/16917012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00708-06
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