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Role of P Glycoprotein in Absorption of Novel Antimalarial Drugs
Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 μM) and low for naphthoquine (5 μM). With 20 μM naphthoquine, net efflux was blocked, suggesting saturation of the transport...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1610088/ https://ncbi.nlm.nih.gov/pubmed/16917012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00708-06 |
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