Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction

Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA n...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Zhang, Limin, Cen, Luan, Qu, Shaogang, Wei, Lei, Mo, Mingshu, Feng, Junmin, Sun, Congcong, Xiao, Yousheng, Luo, Qin, Li, Shaomin, Yang, Xinling, Xu, Pingyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821554/
https://ncbi.nlm.nih.gov/pubmed/27045591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152931
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi