Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction

Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA n...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Limin, Cen, Luan, Qu, Shaogang, Wei, Lei, Mo, Mingshu, Feng, Junmin, Sun, Congcong, Xiao, Yousheng, Luo, Qin, Li, Shaomin, Yang, Xinling, Xu, Pingyi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821554/
https://ncbi.nlm.nih.gov/pubmed/27045591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152931
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