Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction

Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA n...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Zhang, Limin, Cen, Luan, Qu, Shaogang, Wei, Lei, Mo, Mingshu, Feng, Junmin, Sun, Congcong, Xiao, Yousheng, Luo, Qin, Li, Shaomin, Yang, Xinling, Xu, Pingyi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821554/
https://ncbi.nlm.nih.gov/pubmed/27045591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152931
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