NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in response to oxidative stress. Previously, we reported that KEAP1 mutation elicits constitutive NRF2 activation and resistance to cisplatin (CD...

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Vydáno v:PLoS One
Hlavní autoři: Kasai, Shuya, Arakawa, Nobuyuki, Okubo, Ayaka, Shigeeda, Wataru, Yasuhira, Shinji, Masuda, Tomoyuki, Akasaka, Toshihide, Shibazaki, Masahiko, Maesawa, Chihaya
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821458/
https://ncbi.nlm.nih.gov/pubmed/27045471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153181
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