NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in response to oxidative stress. Previously, we reported that KEAP1 mutation elicits constitutive NRF2 activation and resistance to cisplatin (CD...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Kasai, Shuya, Arakawa, Nobuyuki, Okubo, Ayaka, Shigeeda, Wataru, Yasuhira, Shinji, Masuda, Tomoyuki, Akasaka, Toshihide, Shibazaki, Masahiko, Maesawa, Chihaya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821458/
https://ncbi.nlm.nih.gov/pubmed/27045471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153181
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