NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

The KEAP1-NRF2 pathway regulates cellular redox homeostasis by transcriptional induction of genes associated with antioxidant synthesis and detoxification in response to oxidative stress. Previously, we reported that KEAP1 mutation elicits constitutive NRF2 activation and resistance to cisplatin (CD...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kasai, Shuya, Arakawa, Nobuyuki, Okubo, Ayaka, Shigeeda, Wataru, Yasuhira, Shinji, Masuda, Tomoyuki, Akasaka, Toshihide, Shibazaki, Masahiko, Maesawa, Chihaya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821458/
https://ncbi.nlm.nih.gov/pubmed/27045471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153181
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