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Dominant Negative Consequences of a hERG 1b-Specific Mutation Associated with Intrauterine Fetal Death
The human ether-a-go-go related gene (hERG) encodes two subunits, hERG 1a and hERG 1b, that combine in vivo to conduct the rapid delayed rectifier potassium current (I(Kr)). Reduced I(Kr) slows cardiac action potential (AP) repolarization and is an underlying cause of cardiac arrhythmias associated...
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| Udgivet i: | Prog Biophys Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4821159/ https://ncbi.nlm.nih.gov/pubmed/26772437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2016.01.002 |
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