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hERG 1b is critical for human cardiac repolarization
The human ether-à-go-go–related gene (hERG; or KCNH2) encodes the voltage-gated potassium channel underlying I(Kr), a repolarizing current in the heart. Mutations in KCNH2 or pharmacological agents that reduce I(Kr) slow action potential (AP) repolarization and can trigger cardiac arrhythmias associ...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4273358/ https://ncbi.nlm.nih.gov/pubmed/25453103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414945111 |
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