The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

Estrogen is synthesized from cholesterol and high cholesterol levels are suggested to be associated with increased risk of estrogen receptor(ER)-positive breast cancer. The cholesterol metabolite 27-hydroxycholesterol (27-OHC) was recently identified as a selective estrogen receptor modulator (SERM)...

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Vydáno v:Mol Cell Biochem
Hlavní autoři: Raza, Shaneabbas, Ohm, Joyce E., Dhasarathy, Archana, Schommer, Jared, Roche, Conor, Hammer, Kimberly D. P., Ghribi, Othman
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821067/
https://ncbi.nlm.nih.gov/pubmed/26350565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-015-2551-7
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