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ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
Increasing evidence supports that ELL (eleven–nineteen lysine-rich leukaemia) is a key regulator of transcriptional elongation, but the physiological function of Ell in mammals remains elusive. Here we show that ELL functions as an E3 ubiquitin ligase and targets c-Myc for proteasomal degradation. I...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4820845/ https://ncbi.nlm.nih.gov/pubmed/27009366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11057 |
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