A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

AIM: A novel coumarin derivative 7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin (IMM-H004) has shown anti-apoptotic, anti-inflammatory and neuroprotective activities. In this study we investigated the effects of IMM-H004 on spatial memory in rats treated with okadaic acid (OKA), wh...

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Detalles Bibliográficos
Publicado en:Acta Pharmacol Sin
Main Authors: Song, Xiu-yun, Wang, Ying-ying, Chu, Shi-feng, Hu, Jin-feng, Yang, Peng-fei, Zuo, Wei, Song, Lian-kun, Zhang, Shuai, Chen, Nai-hong
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820794/
https://ncbi.nlm.nih.gov/pubmed/26838073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.132
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