BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS

The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a critical modulator of angiogenesis. Increasing evidence indicate the important role of bromodomain and extra-terminal domain (BET) of chromatin adaptors in regulating tumor growth and inflammatory response. Howe...

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Vydáno v:Sci Rep
Hlavní autoři: Huang, Mingcheng, Qiu, Qian, Xiao, Youjun, Zeng, Shan, Zhan, Mingying, Shi, Maohua, Zou, Yaoyao, Ye, Yujin, Liang, Liuqin, Yang, Xiuyan, Xu, Hanshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820704/
https://ncbi.nlm.nih.gov/pubmed/27044328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23770
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