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Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix (ECM), RELN binds to VLDL, APOE2, and α3β2 Integrin receptors located on dendritic shafts and spines of postsynaptic py...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Guidotti, Alessandro, Grayson, Dennis R., Caruncho, Hector J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820443/
https://ncbi.nlm.nih.gov/pubmed/27092053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00089
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