Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulatio...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Nishimoto, Sachiko, Fukuda, Daiju, Higashikuni, Yasutomi, Tanaka, Kimie, Hirata, Yoichiro, Murata, Chie, Kim-Kaneyama, Joo-ri, Sato, Fukiko, Bando, Masahiro, Yagi, Shusuke, Soeki, Takeshi, Hayashi, Tetsuya, Imoto, Issei, Sakaue, Hiroshi, Shimabukuro, Michio, Sata, Masataka
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2016
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820373/
https://ncbi.nlm.nih.gov/pubmed/27051864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501332
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