Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulatio...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Nishimoto, Sachiko, Fukuda, Daiju, Higashikuni, Yasutomi, Tanaka, Kimie, Hirata, Yoichiro, Murata, Chie, Kim-Kaneyama, Joo-ri, Sato, Fukiko, Bando, Masahiro, Yagi, Shusuke, Soeki, Takeshi, Hayashi, Tetsuya, Imoto, Issei, Sakaue, Hiroshi, Shimabukuro, Michio, Sata, Masataka
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820373/
https://ncbi.nlm.nih.gov/pubmed/27051864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501332
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