Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension

BACKGROUND—: The hypertensive syndrome of Apparent Mineralocorticoid Excess is caused by loss-of-function mutations in the gene encoding 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), allowing inappropriate activation of the mineralocorticoid receptor by endogenous glucocorticoid. Hypertension i...

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Vydáno v:Circulation
Hlavní autoři: Evans, Louise C., Ivy, Jessica R., Wyrwoll, Caitlin, McNairn, Julie A., Menzies, Robert I., Christensen, Thorbjørn H., Al-Dujaili, Emad A.S., Kenyon, Christopher J., Mullins, John J., Seckl, Jonathan R., Holmes, Megan C., Bailey, Matthew A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2016
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819772/
https://ncbi.nlm.nih.gov/pubmed/26951843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.019341
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