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Failure to down-regulate the epithelial sodium channel causes salt-sensitivity in Hsd11b2 heterozygote mice
In vivo, the enzyme 11β-hydroxysteroid dehydrogenase type 2 influences ligand access to the mineralocorticoid receptor. Ablation of the encoding gene, HSD11B2, causes the hypertensive syndrome of Apparent Mineralocorticoid Excess. Studies in humans and experimental animals have linked reduced 11β-hy...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428628/ https://ncbi.nlm.nih.gov/pubmed/22777941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.196410 |
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