Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01

Lapatinib is associated with a low incidence of serious liver injury. Previous investigations have identified and confirmed the Class II allele HLA-DRB1*07:01 to be strongly associated with lapatinib-induced liver injury; however, the moderate positive predictive value limits its clinical utility. T...

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Detalhes bibliográficos
Publicado no:Pharmacogenomics J
Main Authors: Parham, L R, Briley, L P, Li, L, Shen, J, Newcombe, P J, King, K S, Slater, A J, Dilthey, A, Iqbal, Z, McVean, G, Cox, C J, Nelson, M R, Spraggs, C F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819766/
https://ncbi.nlm.nih.gov/pubmed/25987243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.40
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