Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons

OBJECTIVE: To determine the extent of respiratory chain abnormalities and investigate the contribution of mtDNA to the loss of respiratory chain complexes (CI–IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single‐neuron level. METHODS: Multiple‐label immunoflu...

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Publicado en:Ann Neurol
Main Authors: Grünewald, Anne, Rygiel, Karolina A., Hepplewhite, Philippa D., Morris, Christopher M., Picard, Martin, Turnbull, Doug M.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819690/
https://ncbi.nlm.nih.gov/pubmed/26605748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24571
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