Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

The major and essential objective of pre-implantation development is to establish embryonic and extra-embryonic cell fates. To address when and how this fundamental process is initiated in mammals, we characterize transcriptomes of all individual cells throughout mouse pre-implantation development....

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Goolam, Mubeen, Scialdone, Antonio, Graham, Sarah J.L., Macaulay, Iain C., Jedrusik, Agnieszka, Hupalowska, Anna, Voet, Thierry, Marioni, John C., Zernicka-Goetz, Magdalena
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819611/
https://ncbi.nlm.nih.gov/pubmed/27015307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.047
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