Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

Ocular neovascular diseases are a leading cause of blindness. Vascular endothelial growth factor (VEGF) blockade improves vision, but not all individuals respond to anti-VEGF treatment, making additional means to prevent neovascularization necessary. Slit-family proteins (Slits) are ligands of Round...

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Bibliographic Details
Published in:Nat Med
Main Authors: Rama, Nicolas, Dubrac, Alexandre, Mathivet, Thomas, Chárthaigh, Róisín-Ana Ní, Genet, Gael, Cristofaro, Brunella, Pibouin-Fragner, Laurence, Ma, Le, Eichmann, Anne, Chédotal, Alain
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819398/
https://ncbi.nlm.nih.gov/pubmed/25894826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3849
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