Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell behaviors are regulated individually is still unknown. Here we identify Endophilin-A2 (ENDOA2), a BAR-domain protein that orchestrates CLATHRIN-independent internalization, as...

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Publicat a:Nat Commun
Autors principals: Genet, Gael, Boyé, Kevin, Mathivet, Thomas, Ola, Roxana, Zhang, Feng, Dubrac, Alexandre, Li, Jinyu, Genet, Nafiisha, Henrique Geraldo, Luiz, Benedetti, Lorena, Künzel, Steffen, Pibouin-Fragner, Laurence, Thomas, Jean-Leon, Eichmann, Anne
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538628/
https://ncbi.nlm.nih.gov/pubmed/31138815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10359-x
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