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α-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein- driven transport in neurons
Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular transport, and defects in this recruitment can cause neurodegenerative disease. Here, we use in vitro reconstitution assays with single molecule resolution, live-cell transport assays in primary neurons, computa...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4819336/ https://ncbi.nlm.nih.gov/pubmed/26972003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.046 |
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