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α-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein- driven transport in neurons

Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular transport, and defects in this recruitment can cause neurodegenerative disease. Here, we use in vitro reconstitution assays with single molecule resolution, live-cell transport assays in primary neurons, computa...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Nirschl, Jeffrey J., Magiera, Maria M., Lazarus, Jacob E., Janke, Carsten, Holzbaur, Erika L. F.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819336/
https://ncbi.nlm.nih.gov/pubmed/26972003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.046
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