Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a common degenerative disease in adult, which is characterized by progressive destruction of the articular cartilage. To investigate the role of FGFR3 in the homeostasis of TMJ cartilage during adult stage, we generated Fgfr3(f/f); Col2a1-C...

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Vydáno v:Sci Rep
Hlavní autoři: Zhou, Siru, Xie, Yangli, Li, Wei, Huang, Junlan, Wang, Zuqiang, Tang, Junzhou, Xu, Wei, Sun, Xianding, Tan, Qiaoyan, Huang, Shuo, Luo, Fengtao, Xu, Meng, Wang, Jun, Wu, Tingting, chen, Liang, Chen, Hangang, Su, Nan, Du, Xiaolan, Shen, Yue, Chen, Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819201/
https://ncbi.nlm.nih.gov/pubmed/27041063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24039
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