NK Cell–Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin are Enhanced by Cytokines

Optimally effective antitumor therapies would not only activate immune effector cells, but engage them at the tumor. Folate-conjugated to immunoglobulin (F-IgG) could direct innate immune cells with Fc receptors to folate receptor–expressing cancer cells. F-IgG bound to human KB and HeLa cells, as w...

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Publicado no:Cancer Immunol Res
Main Authors: Jaime-Ramirez, Alena C., McMichael, Elizabeth, Kondadasula, SriVidya, Skinner, Cassandra C., Mundy-Bosse, Bethany L., Luedke, Eric, Jones, Natalie B., Mani, Aruna, Roda, Julie, Karpa, Volodymyr, Li, Hong, Li, Jilong, Elavazhagan, Saranya, La Perle, Krista M., Schmitt, Alessandra C., Lu, Yanhui, Zhang, Xiaoli, Pan, Xueliang, Mao, Hsaioyin, Davis, Melanie, Jarjoura, David, Butchar, Jonathan P., Poi, Ming, Phelps, Mitch, Tridandapani, Susheela, Byrd, John C., Caligiuri, Michael A., Lee, Robert J., Carson, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818694/
https://ncbi.nlm.nih.gov/pubmed/26865456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0168
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