InsR/IGF1R pathway mediates resistance to EGFR inhibitors in glioblastoma

PURPOSE: Aberrant activation of epidermal growth factor receptor (EGFR) is a hallmark of glioblastoma. However, EGFR inhibitors exhibit at best modest efficacy in glioblastoma. This is in sharp contrast to the observations in EGFR-mutant lung cancer. We examined whether activation of functionally re...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Ma, Yufang, Tang, Nan, Thompson, Reid, Mobley, Bret C., Clark, Steven W., Sarkaria, Jann N., Wang, Jialiang
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818693/
https://ncbi.nlm.nih.gov/pubmed/26561558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1677
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker