Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1()

Yes-associated protein 1 (YAP1) is a transcriptional coactivator in the Hippo signaling pathway. Increased YAP1- activity promotes the growth of tumors, including that of colorectal cancer (CRC). Verteporfin, a drug that enhances phototherapy to treat neovascular macular degeneration, is an inhibito...

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Udgivet i:Sci Signal
Main Authors: Zhang, Huabing, Ramakrishnan, Sadeesh K., Triner, Daniel, Centofanti, Brook, Maitra, Dhiman, Győrffy, Balázs, Sebolt-Leopold, Judith S., Dame, Michael K., Varani, James, Brenner, Dean E., Fearon, Eric R., Omary, M. Bishr, Shah, Yatrik M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818013/
https://ncbi.nlm.nih.gov/pubmed/26443705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac5418
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