Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration

Degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is essential for vision, and studies have implicated altered POS processing in the pathogenesis of some retinal degenerative diseases. Consistent with this concept, a recently established hiPSC-RPE model of inherit...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Singh, Ruchira, Kuai, David, Guziewicz, Karina E, Meyer, Jackelyn, Wilson, Molly, Lu, Jianfeng, Smith, Molly, Clark, Eric, Verhoeven, Amelia, Aguirre, Gustavo D, Gamm, David M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817951/
https://ncbi.nlm.nih.gov/pubmed/26300224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.141
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