CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors

A human single-chain variable fragment (scFv) antibody library was expressed on the surface of human T cells after transduction with lentiviral vectors (LVs). The repertoire was fused to a first-generation T cell receptor ζ (TCRζ)-based chimeric antigen receptor (CAR). We used this library to isolat...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Alonso-Camino, Vanesa, Sánchez-Martín, David, Compte, Marta, Nuñez-Prado, Natalia, Diaz, Rosa M, Vile, Richard, Alvarez-Vallina, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Methods - Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817937/
https://ncbi.nlm.nih.gov/pubmed/23695536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.19
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