S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction

Restoring expression levels of the EF-hand calcium (Ca(2+)) sensor protein S100A1 has emerged as a key factor in reconstituting normal Ca(2+) handling in failing myocardium. Improved sarcoplasmic reticulum (SR) function with enhanced Ca(2+) resequestration appears critical for S100A1's cyclic a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Ther
Egile Nagusiak: Ritterhoff, Julia, Völkers, Mirko, Seitz, Andreas, Spaich, Kristin, Gao, Erhe, Peppel, Karsten, Pleger, Sven T, Zimmermann, Wolfram H, Friedrich, Oliver, Fink, Rainer H A, Koch, Walter J, Katus, Hugo A, Most, Patrick
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817858/
https://ncbi.nlm.nih.gov/pubmed/26005840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.93
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