Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome Polymorphisms

Bacille Calmette–Guérin (BCG), an attenuated strain of Mycobacterium bovis, is the only vaccine available for tuberculosis (TB) control. However, BCG is not an ideal vaccine and has two major limitations: BCG exhibits highly variable effectiveness against the development of TB both in pediatric and...

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Vydáno v:Mol Ther
Hlavní autoři: Zhang, Lu, Ru, Huan-wei, Chen, Fu-zeng, Jin, Chun-yan, Sun, Rui-feng, Fan, Xiao-yong, Guo, Ming, Mai, Jun-tao, Xu, Wen-xi, Lin, Qing-xia, Liu, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817822/
https://ncbi.nlm.nih.gov/pubmed/26643797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.216
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