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Novel genome polymorphisms in BCG vaccine strains and impact on efficacy

Bacille Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis currently used as a vaccine against tuberculosis. Global distribution and propagation of BCG has contributed to the in vitro evolution of the vaccine strain and is thought to partially account for the different outcomes of...

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Autors principals: Leung, Andrea S, Tran, Vanessa, Wu, Zuowei, Yu, Xuping, Alexander, David C, Gao, George Fu, Zhu, Baoli, Liu, Jun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553098/
https://ncbi.nlm.nih.gov/pubmed/18793412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-413
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