A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cells

Monoclonal antibodies directed to the B-cell-specific CD20-antigen are successfully used for the treatment of lymphomas and autoimmune diseases. Here, we compare the anti-B-cell activity of three different antibodies directed to CD20: (i) a chimeric, monospecific antibody, (ii) an Fc-optimized varia...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Nalivaiko, Kristina, Hofmann, Martin, Kober, Karina, Teichweyde, Nadine, Krammer, Peter H, Rammensee, Hans-Georg, Grosse-Hovest, Ludger, Jung, Gundram
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817817/
https://ncbi.nlm.nih.gov/pubmed/26581163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.209
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