Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency of the lysosomal enzyme arylsulfatase A. The prevailing late-infantile variant of MLD is characterized by widespread and progressive demyelination of the central nervous system (CNS) causing death dur...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther
Hoofdauteurs: Stein, Axel, Stroobants, Stijn, Gieselmann, Volkmar, D'Hooge, Rudi, Matzner, Ulrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817791/
https://ncbi.nlm.nih.gov/pubmed/25896249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.69
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