Anti-inflammatory Therapy With Simvastatin Improves Neuroinflammation and CNS Function in a Mouse Model of Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency of the lysosomal enzyme arylsulfatase A. The prevailing late-infantile variant of MLD is characterized by widespread and progressive demyelination of the central nervous system (CNS) causing death dur...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Stein, Axel, Stroobants, Stijn, Gieselmann, Volkmar, D'Hooge, Rudi, Matzner, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817791/
https://ncbi.nlm.nih.gov/pubmed/25896249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.69
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