Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients

Leptin treatment has beneficial effects on plasma lipids in patients with lipodystrophy, but the underlying mechanism is unknown. Proprotein convertase subtilisin/kexin type 9 (PCSK9) decreases low-density lipoprotein (LDL) clearance, promotes hypercholesterolemia, and has recently emerged as a nove...

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Dettagli Bibliografici
Pubblicato in:Endocrinology
Autori principali: Levenson, Amy E., Haas, Mary E., Miao, Ji, Brown, Rebecca J., de Ferranti, Sarah D., Muniyappa, Ranganath, Biddinger, Sudha B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816729/
https://ncbi.nlm.nih.gov/pubmed/26824363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1624
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