Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhibition of ERK suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines and that concurrent PI3K in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell
Egile Nagusiak: Hayes, Tikvah K., Neel, Nicole F., Hu, Chaoxin, Gautam, Prson, Chenard, Melissa, Long, Brian, Aziz, Meraj, Kassner, Michelle, Bryant, Kirsten L., Pierobon, Mariaelena, Marayati, Raoud, Kher, Swapnil, George, Samuel D., Xu, Mai, Wang-Gillam, Andrea, Samatar, Ahmed A., Maitra, Anirban, Wennerberg, Krister, Petricoin, Emanuel F., Yin, Hongwei H., Nelkin, Barry, Cox, Adrienne D., Yeh, Jen Jen, Der, Channing J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816652/
https://ncbi.nlm.nih.gov/pubmed/26725216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.11.011
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