Atypical KRAS(G12R) Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

Allele-specific signaling by different KRAS alleles remains poorly understood. The KRAS(G12R) mutation displays uneven prevalence among cancers that harbor the highest occurrence of KRAS mutations: it is rare in lung and colorectal cancers (~1%), yet relatively common (~20%) in pancreatic ductal ade...

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Bibliografiska uppgifter
I publikationen:Cancer Discov
Huvudupphovsmän: Hobbs, G. Aaron, Baker, Nicole M., Miermont, Anne M., Thurman, Ryan D., Pierobon, Mariaelena, Tran, Timothy H., Anderson, Andrew O., Waters, Andrew M., Diehl, J. Nathaniel, Papke, Bjoern, Hodge, Richard G., Klomp, Jennifer E., Goodwin, Craig M., DeLiberty, Jonathan M., Wang, Junning, Ng, Raymond W. S., Gautam, Prson, Bryant, Kirsten L., Esposito, Dominic, Campbell, Sharon L., Petricoin, Emanuel F., Simanshu, Dhirendra K., Aguirre, Andrew J., Wolpin, Brian M., Wennerberg, Krister, Rudloff, Udo, Cox, Adrienne D., Der, Channing J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954322/
https://ncbi.nlm.nih.gov/pubmed/31649109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1006
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