siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based siRNA screen. We revealed an actin-remodeling pa...

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Publicado en:PLoS Pathog
Autores principales: Radoshitzky, Sheli R., Pegoraro, Gianluca, Chī, Xiǎolì, Dǒng, Lián, Chiang, Chih-Yuan, Jozwick, Lucas, Clester, Jeremiah C., Cooper, Christopher L., Courier, Duane, Langan, David P., Underwood, Knashka, Kuehl, Kathleen A., Sun, Mei G., Caì, Yíngyún, Yú, Shuǐqìng, Burk, Robin, Zamani, Rouzbeh, Kota, Krishna, Kuhn, Jens H., Bavari, Sina
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816540/
https://ncbi.nlm.nih.gov/pubmed/27031835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005466
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