siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based siRNA screen. We revealed an actin-remodeling pa...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Radoshitzky, Sheli R., Pegoraro, Gianluca, Chī, Xiǎolì, Dǒng, Lián, Chiang, Chih-Yuan, Jozwick, Lucas, Clester, Jeremiah C., Cooper, Christopher L., Courier, Duane, Langan, David P., Underwood, Knashka, Kuehl, Kathleen A., Sun, Mei G., Caì, Yíngyún, Yú, Shuǐqìng, Burk, Robin, Zamani, Rouzbeh, Kota, Krishna, Kuhn, Jens H., Bavari, Sina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816540/
https://ncbi.nlm.nih.gov/pubmed/27031835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005466
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