Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms

Glioblastoma is a very aggressive form of brain tumor with limited therapeutic options. Usually, glioblastoma is treated with ionizing radiation (IR) and chemotherapy after surgical removal. However, radiotherapy is frequently unsuccessful, among others owing to resistance mechanisms the tumor cells...

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Publicat a:Cell Death Dis
Autors principals: Wolfsperger, F, Hogh-Binder, S A, Schittenhelm, J, Psaras, T, Ritter, V, Bornes, L, Huber, S M, Jendrossek, V, Rudner, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816183/
https://ncbi.nlm.nih.gov/pubmed/26775694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.405
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