P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development

It has been shown that p53 has a critical role in the differentiation and functionality of various multipotent progenitor cells. P53 mutations can lead to genome instability and subsequent functional alterations and aberrant transformation of mesenchymal stem cells (MSCs). The significance of p53 in...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Velletri, T, Xie, N, Wang, Y, Huang, Y, Yang, Q, Chen, X, Chen, Q, Shou, P, Gan, Y, Cao, G, Melino, G, Shi, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816167/
https://ncbi.nlm.nih.gov/pubmed/26775693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.367
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