Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin

p53 plays a pivotal role in controlling the differentiation of mesenchymal stem cells (MSCs) by regulating genes involved in cell cycle and early steps of differentiation process. In the context of osteogenic differentiation of MSCs and bone homeostasis, the osteoprotegerin/receptor activator of NF-...

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Publicado no:Cell Death Differ
Main Authors: Velletri, Tania, Huang, Yin, Wang, Yu, Li, Qing, Hu, Mingyuan, Xie, Ningxia, Yang, Qian, Chen, Xiaodong, Chen, Qing, Shou, Peishun, Gan, Yurun, Candi, Eleonora, Annicchiarico-Petruzzelli, Margherita, Agostini, Massimiliano, Yang, Huilin, Melino, Gerry, Shi, Yufang, Wang, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853126/
https://ncbi.nlm.nih.gov/pubmed/32694652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0590-4
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