P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development

It has been shown that p53 has a critical role in the differentiation and functionality of various multipotent progenitor cells. P53 mutations can lead to genome instability and subsequent functional alterations and aberrant transformation of mesenchymal stem cells (MSCs). The significance of p53 in...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Velletri, T, Xie, N, Wang, Y, Huang, Y, Yang, Q, Chen, X, Chen, Q, Shou, P, Gan, Y, Cao, G, Melino, G, Shi, Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816167/
https://ncbi.nlm.nih.gov/pubmed/26775693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.367
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