NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

NF-κB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-κB2 processing into p52, a process defined as the alternative, or non-canonical, NF-κB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-dependent apoptosis, a consequence of TNFR1 activation obser...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Boutaffala, L, Bertrand, M J M, Remouchamps, C, Seleznik, G, Reisinger, F, Janas, M, Bénézech, C, Fernandes, M T, Marchetti, S, Mair, F, Ganeff, C, Hupalowska, A, Ricci, J-E, Becher, B, Piette, J, Knolle, P, Caamano, J, Vandenabeele, P, Heikenwalder, M, Dejardin, E
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816116/
https://ncbi.nlm.nih.gov/pubmed/26045047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.69
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker